Combines deep mutational scanning, structural analysis, and ESM3 prompt engineering to design synthetic TnpB-family nucleases with up to 3x higher editing activity at human loci despite low sequence identity.
Weekly roundupWeek of August 24, 2026
Research Roundup
Four papers mapping a faster path through biological design space. A curated roundup of the preprints supplied for this week, across computational biology and protein engineering.
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Alternates inverse-folding and structure-prediction models to generate physically plausible intermediate conformations between structural anchor states without requiring MD training data.
Maps ligand-binding sites into a low-dimensional latent space using pLM features and SE(3)-invariant graph VAEs, enabling vector similarity search with ~3,400-fold lower cost than ProBiS.
Combines and compresses pairwise pLM embeddings to build a joint latent representation of protein-protein interactions for functional analysis.